Case Study Essay Example | Topics and Well Written Essays - 250 words - 17

Case Study - Essay Example 3. Testing for carrier or affected individuals with Tay-Sachs disease; blood screening for hexosaminidase-A (Hex-A) mutation in suspected individual that either have family history or are of Ashkenazi Jewish descent is used to identify carriers. Blood test is performed antenatal using chronic villus sampling and amniocentesis or after birth. 5. Function of lysosomes; they produce enzyme Hexosaminidase-A (Hex-A) that prevents buildup of fatty materials called GM2 ganglioside in the cells brain and nerves. This further averts malfunctioning of nerves and brain cells (Americo, Filho, & Shapiro, 2010). 6. Role of Hexosaminidase-A enzyme; this enzyme is responsible for abasement of GM2 ganglioside and many other biological molecules that have terminal N-acetyl hexosamins in both the brain cells and nervous cells. Deficiency of enzyme hexosaminidase A causes Tay-Sachs disease due to increased buildup of toxic GM2 ganglioside a fatty substance that destroys brain cells and nerves. This results in motor difficulties and other signs and symptoms. 7. Diagnosis of Tay-Sachs disease; blood test is analyzed for enzyme assay or biochemical examination that reveals the levels of hexosaminidase- A in an individual. Affected individuals have less -hexosaminidase A blood and other cells than non-carriers. 8. Management; Tay-Sachs disease has no cure; only management is to relieve symptoms. Prevent airway and lung problems; relieve dysphagia and medication for fits, muscle stiffness and eye problems (Chamoles, Blanco, Gaggioli, & Casentini, 2002). Chamoles, N. A., Blanco, M., Gaggioli, D., & Casentini, C. (2002). Tay-Sachs and Sandhoff diseases: Enzymatic diagnosis in dried blood spots on filter paper: Retrospective diagnoses in newborn-screening cards. Clinica Chimica Acta, 318(1-2), 133–137. doi:10.1016/S0009-8981(02)00002-5 Ohno, K., Saito, S., Sugawara, K., & Sakuraba, H. (2008). Structural

Testing anti-bacterial agents Essay Example | Topics and Well Written Essays - 250 words

Testing anti-bacterial agents - Essay Example Firstly, the infected cell may be exposed to different types of quinolone antibacterial. Secondly, McCoy cell monolayers should inoculate with 103 (IFU) OF C. trachomatis then incubated with or without ofloxacin. Result: The main results of testing anti-bacterial agents will show in this paragraph. The effects of four types of antibacterial (Ofloxacin, Ciprofloxacin, Enoxacin, and Norfloxacin) in McCoy cell are different. The results may refer to the different abilities for each antibacterial to penetrate the eukaryotic cell. Moreover, the infected cell may not increase the time of incubation after the removal of anti-bacterial agents creating a little different between MIC and MLC for each antibacterial agent. On the other hand, Ofloxacin antibacterial agent may act contrary to some enzymes that are important for the survival of non-replicating intracellular chlamydia. As such, Ofloxacin has a responsibility of treating the determined and calm infection. Conclusion: This study deriv es and presents four important points. Firstly, quinolone antibacterial agent acts quickly against chlamydia. Secondly, Ofloxacin considers suitable antimicrobial agent against chlamydia infection. Thirdly, humans can achieve and maintain 1mg/l of Ofloxacin in serum. Therefore, the clinical experiment against chlamydia infection will be of interest. Finally, Ofloxacin may give us a tool to show the importance of DNA metabolism in non-replicating intracellular chlamydia organized by topoisomerases.